Mitosis (With Diagram) | Cell Cycle
A proteinaceous factor termed as maturation promoting factor (MPF), subsequently renamed as mitosis promoting factor, is identified and purified (Masui, Markert, Mailer). MPF is a heterodimer complex between kinase - a catalytic sub- unit and cyclin - a regulatory subunit (Fig. 5.27A). Kinase enzyme brings about phosphorylation of specific target proteins at different stages of the cell cycle which is [...]