Short Notes on Nalidixic Acid | Antibiotics

Nalidixic acid is credited to be the first quinolone synthesized in laboratory in 1962. Its chemical structure is shown in Fig. 45.16. It is a broad spectrum chemotherapeutic agent and is useful against gram-negative bacteria (causing urinary tract infection) and some gram-positive ones. Nalidixic acid is bactericidal and is effective when administered orally. This antibiotic sometimes causes side effects, particularly [...]