The below mentioned article provides a short note on the Economics of Carbohydrate and Lipid Metabolism in the whole body. Glucose is converted to fat under optimal nutritional intake. Except glycerol, fat (as fatty acid) cannot produce glucose due to the irreversibility of the oxidative decarboxylation of pyruvate to acetyl-CoA. Certain tissues are more dependent on the continued supply of [...]
The following points highlight the top two stages for regulation of lipid metabolism. The stages are: 1. Regulation of Lipogenesis 2. Regulation of Ketogenesis. Regulation of Lipogenesis: a. Lipogenesis is concerned with the conversion of glucose and intermediate such as pyruvate, lactate and acetyl-CoA to fat. b. The rate of lipogenesis is high in case of a diet containing a [...]
The following points highlight the six major diseases caused due to errors in lipid metabolism. The diseases are: 1. Gaucher's Disease 2. Niemann-Pick Disease 3. Tay-Sach's Disease 4. Fabry's Disease 5. Refsum's Disease 6. Krabbe's Disease. Errors in Lipid Metabolism: Disease # 1. Gaucher's Disease: In this disease, the cerebroside content of the reticuloendothelial cells (e.g., spleen) is very high. [...]