In this article we will discuss about the structure of immunoglobulins, explained with the help of a suitable diagram. Identification of antibodies in the serum protein fraction was demonstrated in the classic experiments of A. Tiselius and E.A. Kabat in 1939. However, the basic structure of —globulin molecule was revealed by Rodney R. Porter and Gerald Edehman in 1950s and [...]
In this article we will discuss about Immunoglobulins:- 1. Structure of Immunoglobulins 2. Classification of Immunoglobulins 3. Electrophoretic Determination 4. Quantitative Determination. Structure of Immunoglobulins: a. The basic unit of all immunoglobulin molecules consists of 4 polypeptide chains linked by disulfide bonds shown in Fig. 30.1 b. There are two identical heavy (H) chains (MW 53,000-75,000) and two identical light [...]
In this article we will discuss about Antibodies:- 1. History of Antibodies 2. The Nature of Antibodies 3. Immunoglobulin G or IgG 4. Kinds of Antibodies. History of Antibodies: Von Behring and Kitasato in Berlin in 19th century recognised antibodies in the blood stream of an immunized animal against tetanus and diphtheria. They observed clumping or agglutination of microorganisms and [...]