The following points highlight the eight main criticisms for Lyon’s hypothesis. Criticism # 1. That XO, XXX, XY, XX etc. individual differ among themselves suggesting that the entire X chromosome is not genetically inactive. If it were so, an XX and XXX female would have had no difference at all. From various chemical stigmata it seems that a part of [...]
The three examples of autosome-linked genetic disease are: 1. Sickle Cell Anemia 2. Alkaptonuria (Black Urine Disease) 3. Phenylketonuria. Example # 1. Sickle Cell Anemia: Sickle cell anemia is an inherited abnormal disease caused by mutation of autosomal gene. The red blood cells of certain individuals have peculiar property of undergoing reversible alterations in shape when subjected to changes in [...]
In this article we will discuss about:- 1. Dosage Compensation and Sex-Chromatin Bodies 2. Details about Dosage Compensation or Lyon's Hypothesis 3. Objectives behind the Proposition of Lyon's Hypothesis and 4. Evidences in Support of Lyon's Hypothesis. Dosage Compensation and Sex-Chromatin Bodies: In man it has been found that Y-chromosomes are genetically inert in comparison to the X-chromosomes and other [...]