Genetics of Thalassemia

In this article we will discuss about the genetics of thalassemia. There are two main types of thalas­semia: α-thalassemia — resulting from a reduced rate of α-chain; β-thalassemia — resulting from a defective production of β-chains. More recently, family studies have revealed a heterogeneity of both α and β- thalassemia which is discussed in the Table 15.1. The β-thalassemias are [...]