The below mentioned article provides a short note on Microtubule and Spindle. During the process of cell division the cytoplasmic network of microtubules disappears and the microtubules are reassembled in the form of spindle in the dividing cell (in both mitotic and meiotic cell division). Though the controlling pattern of this disappearance and recognized is not very clear, but it [...]
In this article we will discuss about:- 1. Introduction to Apoptosis 2. Cellular Events of Apoptosis 3. Mechanism 4. Importance. Introduction to Apoptosis: Every normal living cell of animals, plants and even bacteria are mortal. I.e., they must die after some time. Cell death is a finely tuned programme inherent in the cells genetic machinery. This normal cell death which [...]
A proteinaceous factor termed as maturation promoting factor (MPF), subsequently renamed as mitosis promoting factor, is identified and purified (Masui, Markert, Mailer). MPF is a heterodimer complex between kinase - a catalytic sub- unit and cyclin - a regulatory subunit (Fig. 5.27A). Kinase enzyme brings about phosphorylation of specific target proteins at different stages of the cell cycle which is [...]