This article provides an overview on hypnotics and sedatives. Hypnotics are drugs which produce drowsiness and facilitate the onset and maintenance of a state of sleep resembling natural sleep in its electroencephalogram (EEG) features and from which the recipient may be easily aroused. The effect produced by hypnotics is known as hypnosis. Sedatives are the drug which moderately depress the [...]
The transmitters, central or peripheral, may be conveniently classified into two categories: 1. Non-peptide transmitter with molecular weight less than 200. These include amines and amino acids. The amines include acetylcholine (a tertiary amine) and biogenic amines e.g. dopamine, serotonin (5-HT), norepinephrine, epinephrine and histamine. The amino acids include glycine and GABA (monocarboxylic; inhibitory), and glutamate/aspartate (dicarboxylic; excitatory), and 2. [...]
After reading this article we will learn about the synthesis of Acetylcholine (Ach). Acetylcholine (Ach) is the neurotransmitter at parasympathetic neuro-effector junctions, all autonomic ganglia, adrenal medulla, somatic neuromuscular junctions, and CNS. Synthesis, Storage and Release of Ach: Ach is synthesized in the cholinergic nerve endings. After a reaction among acetate, coenzyme A and ATP, acetyl CoA is formed within [...]